A cytotoxic glycoside macrolide, callipeltoside A (I), has been isolated from the marine lithistid sponge Callipelta sp., collected off New Caledonia. Structural assignment was accomplished through extensive 2D NMR spectroscopy. The complete relative stereochem. is proposed from the anal. of ROESY and NOE difference expts. Callipeltoside A represents the first member of a new class of marine-derived macrolides, contg. unusual structural features including a 4- amino-4,6-dideoxy-2-O,3-C-dimethyl-a-talopyranosyl-3,4-urethane unit.
Callipeltoside A: a cytotoxic aminodeoxy sugar-containing macrolide of a new type from the marine lithistidasponge Callipelta sp / Zampella, Angela; D'Auria, MARIA VALERIA; Minale, L.; Debitus, C.; Roussakis, C.. - In: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. - ISSN 0002-7863. - STAMPA. - 118:45(1996), pp. 11085-11088. [10.1021/ja9621004]
Callipeltoside A: a cytotoxic aminodeoxy sugar-containing macrolide of a new type from the marine lithistidasponge Callipelta sp
ZAMPELLA, ANGELA;D'AURIA, MARIA VALERIA;
1996
Abstract
A cytotoxic glycoside macrolide, callipeltoside A (I), has been isolated from the marine lithistid sponge Callipelta sp., collected off New Caledonia. Structural assignment was accomplished through extensive 2D NMR spectroscopy. The complete relative stereochem. is proposed from the anal. of ROESY and NOE difference expts. Callipeltoside A represents the first member of a new class of marine-derived macrolides, contg. unusual structural features including a 4- amino-4,6-dideoxy-2-O,3-C-dimethyl-a-talopyranosyl-3,4-urethane unit.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
