A new nonsym. dimeric steroid, crellastatin A (I), was isolated from the Vanuatu Island marine sponge Crella sp. Structural assignment was accomplished through extensive 2D NMR spectroscopy. The stereochem. of I was established from an anal. of ROESY expts. and from mol. mechanics and dynamics calcns. I, which possesses an unprecedented connection through the side chains, exhibits in vitro cytotoxic activity against NSCLC-N6 cells (IC50 of 1.5 mg/mL).
Crellastatin A: a cytotoxic bis-steroid sulfate from the Vanuatu marine sponge Crella sp / D'Auria, MARIA VALERIA; Giannini, C.; Zampella, Angela; Minale, L.; Debitus, C.; Roussakis, C.. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - STAMPA. - 63:21(1998), pp. 7382-7388. [10.1021/jo981022v]
Crellastatin A: a cytotoxic bis-steroid sulfate from the Vanuatu marine sponge Crella sp
D'AURIA, MARIA VALERIA;ZAMPELLA, ANGELA;
1998
Abstract
A new nonsym. dimeric steroid, crellastatin A (I), was isolated from the Vanuatu Island marine sponge Crella sp. Structural assignment was accomplished through extensive 2D NMR spectroscopy. The stereochem. of I was established from an anal. of ROESY expts. and from mol. mechanics and dynamics calcns. I, which possesses an unprecedented connection through the side chains, exhibits in vitro cytotoxic activity against NSCLC-N6 cells (IC50 of 1.5 mg/mL).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
