Seven new cytotoxic dimeric steroids, crellastatins B-H, were isolated from the Vanuatu sponge Crella sp. They were structurally characterized on the basis of 2D-NMR (500 MHz) and FAB-MS data. All the new compds. show the same unprecedented junction between the monomeric units, formed via their side-chains, whereas they differ from crellastatin A in the hydroxylation pattern of the 2 tetracyclic cores. Like crellastatin A , crellastatins B-H exhibit in vitro antitumor activity against human bronchopulmonary non-small-cell lung carcinoma cell lines (NSCLC) with IC50 values in the range of 2-10 mg/mL.
Isolation and structural elucidation of crellastatins B-H. Cytotoxic bis(steroid) derivatives from the Vanuatumarine sponge Crella / Zampella, Angela; Giannini, C.; Debitus, C.; Roussakis, C.; D'Auria, MARIA VALERIA. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - STAMPA. - 4(1999), pp. 949-953. [10.1002/(SICI)1099-0690(199904)1999:4]
Isolation and structural elucidation of crellastatins B-H. Cytotoxic bis(steroid) derivatives from the Vanuatumarine sponge Crella
ZAMPELLA, ANGELA;D'AURIA, MARIA VALERIA
1999
Abstract
Seven new cytotoxic dimeric steroids, crellastatins B-H, were isolated from the Vanuatu sponge Crella sp. They were structurally characterized on the basis of 2D-NMR (500 MHz) and FAB-MS data. All the new compds. show the same unprecedented junction between the monomeric units, formed via their side-chains, whereas they differ from crellastatin A in the hydroxylation pattern of the 2 tetracyclic cores. Like crellastatin A , crellastatins B-H exhibit in vitro antitumor activity against human bronchopulmonary non-small-cell lung carcinoma cell lines (NSCLC) with IC50 values in the range of 2-10 mg/mL.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
