Cancer, particularly gastric cancer (GC), is prevalently an epigenetic phenomenon that is dependent on an altered DNA methylation pattern. In gastric carcinogenesis, many genes show aberrant methylation; however, none of them may be used as a biomarker of cancer risk and progression. The authors aimed to evaluate the global DNA methylation of gastric mucosa in Helicobacter pylori (Hp)-related chronic gastritis, in GC and in 10 patients with preneoplastic lesions (ie, atrophy and intestinal metaplasia) followed up for 10 years.

Global DNA hypomethylation is an early event in Helicobacter pylori-related gastric carcinogenesis / Compare, Debora; Rocco, Alba; Liguori, E; D'Armiento, FRANCESCO PAOLO; Persico, Giovanni; Masone, Stefania; Coppola Bottazzi, E; Suriani, R; Romano, Marina; Nardone, GERARDO ANTONIO PIO. - In: JOURNAL OF CLINICAL PATHOLOGY. - ISSN 0021-9746. - 64:8(2011), pp. 677-682.

Global DNA hypomethylation is an early event in Helicobacter pylori-related gastric carcinogenesis.

COMPARE, DEBORA;ROCCO, ALBA;D'ARMIENTO, FRANCESCO PAOLO;PERSICO, GIOVANNI;MASONE, STEFANIA;ROMANO, MARINA;NARDONE, GERARDO ANTONIO PIO
2011

Abstract

Cancer, particularly gastric cancer (GC), is prevalently an epigenetic phenomenon that is dependent on an altered DNA methylation pattern. In gastric carcinogenesis, many genes show aberrant methylation; however, none of them may be used as a biomarker of cancer risk and progression. The authors aimed to evaluate the global DNA methylation of gastric mucosa in Helicobacter pylori (Hp)-related chronic gastritis, in GC and in 10 patients with preneoplastic lesions (ie, atrophy and intestinal metaplasia) followed up for 10 years.
2011
Global DNA hypomethylation is an early event in Helicobacter pylori-related gastric carcinogenesis / Compare, Debora; Rocco, Alba; Liguori, E; D'Armiento, FRANCESCO PAOLO; Persico, Giovanni; Masone, Stefania; Coppola Bottazzi, E; Suriani, R; Romano, Marina; Nardone, GERARDO ANTONIO PIO. - In: JOURNAL OF CLINICAL PATHOLOGY. - ISSN 0021-9746. - 64:8(2011), pp. 677-682.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/410200
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 49
  • ???jsp.display-item.citation.isi??? 44
social impact