Insulin protects cardiomyocytes from apoptosis. Insulin resistance usually refers to a defect in the ability of insulin to stimulate glucose uptake. It is unknown, however, whether or not insulin resistance compromises the cell-protective effect of the hormone. Caspases are a family of cysteine proteases that regulate apoptosis.We explored the effects of insulin resistance on hypoxia-induced caspase-3 activation in cardiomyocytes.
Insulin resistance affects the cytoprotective effect of insulin in cardiomyocytes through an impairment of MAPK phosphatase-1 expression / Morisco, Carmine; Marrone, C; Trimarco, Valentina; Crispo, S; Monti, MARIA GAIA; Sadoshima, J; Trimarco, Bruno. - In: CARDIOVASCULAR RESEARCH. - ISSN 0008-6363. - STAMPA. - 76:3(2007), pp. 453-464.
Insulin resistance affects the cytoprotective effect of insulin in cardiomyocytes through an impairment of MAPK phosphatase-1 expression.
MORISCO, CARMINE;TRIMARCO, VALENTINA;MONTI, MARIA GAIA;TRIMARCO, BRUNO
2007
Abstract
Insulin protects cardiomyocytes from apoptosis. Insulin resistance usually refers to a defect in the ability of insulin to stimulate glucose uptake. It is unknown, however, whether or not insulin resistance compromises the cell-protective effect of the hormone. Caspases are a family of cysteine proteases that regulate apoptosis.We explored the effects of insulin resistance on hypoxia-induced caspase-3 activation in cardiomyocytes.File | Dimensione | Formato | |
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