The conformational behavior of a heterodetic bicyclic decapeptide (BCPLT) in the absence and in the presence of calcium ions has been studied by means of mono and two-dimensional nmr techniques. Free BCPLT possesses a quite compact structure stabilized by intramolecular bonds and turns. In the structure a cluster of carbonyls is located in a cavity that is supposed to be the cation binding site.

BICYCLIC PEPTIDES - SOLUTION CONFORMATION AND CA-2+ BINDING OF THE HETERODETIC BICYCLIC DECAPEPTIDE CYCLO(GLU1-LEU2-PRO3-GLY4-SER5-ILE6-PRO7-ALA8)-CYCLO(1-GAMMA- 5-BETA) PHE9-GLY10

PAOLILLO, LIVIO;D'AURIA, GABRIELLA;
1989

Abstract

The conformational behavior of a heterodetic bicyclic decapeptide (BCPLT) in the absence and in the presence of calcium ions has been studied by means of mono and two-dimensional nmr techniques. Free BCPLT possesses a quite compact structure stabilized by intramolecular bonds and turns. In the structure a cluster of carbonyls is located in a cavity that is supposed to be the cation binding site.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/404577
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