The proton NMR characterization of bombesin has been carried out at 500 MHz in DMSO-d6 using two-dimensional homo- and 1H-13C hetero-correlated techniques. All resonances in the NMR spectra have been assigned and several coupling constants have been measured. The backbone JαCH-NH coupling constants have constant values that vary between 7.8 and 8.2 Hz and indicate an unfolded structure in DMSO-d6. Discrepancies with data recently obtained at 300 MHz [(1987) Eur. J. Biochem. 168, 193–199] are discussed.

500 MHZ NMR CHARACTERIZATION OF SYNTHETIC BOMBESIN AND RELATED PEPTIDES IN DMSO-D6 BY TWO-DIMENSIONAL TECHNIQUES / Di Bello, C.; Gozzini, L.; Tonellato, M.; Corradini, M. G.; D'Auria, Gabriella; Paolillo, Livio; Trivellone, E.. - In: FEBS LETTERS. - ISSN 0014-5793. - ELETTRONICO. - 237:(1988), pp. 85-90. [10.1016/0014-5793(88)80177-7]

500 MHZ NMR CHARACTERIZATION OF SYNTHETIC BOMBESIN AND RELATED PEPTIDES IN DMSO-D6 BY TWO-DIMENSIONAL TECHNIQUES

D'AURIA, GABRIELLA;PAOLILLO, LIVIO;
1988

Abstract

The proton NMR characterization of bombesin has been carried out at 500 MHz in DMSO-d6 using two-dimensional homo- and 1H-13C hetero-correlated techniques. All resonances in the NMR spectra have been assigned and several coupling constants have been measured. The backbone JαCH-NH coupling constants have constant values that vary between 7.8 and 8.2 Hz and indicate an unfolded structure in DMSO-d6. Discrepancies with data recently obtained at 300 MHz [(1987) Eur. J. Biochem. 168, 193–199] are discussed.
1988
500 MHZ NMR CHARACTERIZATION OF SYNTHETIC BOMBESIN AND RELATED PEPTIDES IN DMSO-D6 BY TWO-DIMENSIONAL TECHNIQUES / Di Bello, C.; Gozzini, L.; Tonellato, M.; Corradini, M. G.; D'Auria, Gabriella; Paolillo, Livio; Trivellone, E.. - In: FEBS LETTERS. - ISSN 0014-5793. - ELETTRONICO. - 237:(1988), pp. 85-90. [10.1016/0014-5793(88)80177-7]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/404557
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