No pigs, no cows needed: Chondroitin sulfate for pharmacological uses is obtained from animal sources in low abundance and with a laborious downstream purification. It has now been synthesized for the first time by an innovative microbiological-chemical approach consisting of chondroitin production from E. coli K4 fed-batch fermentation and its subsequent regioselective sulfation in five steps and 61 % overall yield (see scheme).
A Microbiological-Chemical Strategy to Produce Chondroitin Sulfate A,C / Bedini, Emiliano; DE CASTRO, Cristina; M., De Rosa; A., Di Nola; Iadonisi, Alfonso; O. F., Restaino; C., Schiraldi; Parrilli, Michelangelo; Restaino, ODILE FRANCESCA. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 50:(2011), pp. 6160-6163. [10.1002/anie.201101142]
A Microbiological-Chemical Strategy to Produce Chondroitin Sulfate A,C.
BEDINI, EMILIANO;DE CASTRO, CRISTINA;IADONISI, ALFONSO;PARRILLI, MICHELANGELO;O. F. Restaino
2011
Abstract
No pigs, no cows needed: Chondroitin sulfate for pharmacological uses is obtained from animal sources in low abundance and with a laborious downstream purification. It has now been synthesized for the first time by an innovative microbiological-chemical approach consisting of chondroitin production from E. coli K4 fed-batch fermentation and its subsequent regioselective sulfation in five steps and 61 % overall yield (see scheme).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
