Chemical analysis of the Mediterranean ascidian Polyandrocarpa zorritensis (Van Name 1931) resulted in the isolation of a series of molecules including two monoindole alkaloids, 3-indolylglyoxylic acid (3) and its methyl ester (4), 4-hydroxy-3-methoxyphenylglyoxylic acid methyl ester (1) and a new alkaloid we named zorrimidazolone (2). The structure of the novel compound 2 has been elucidated by spectroscopic analysis and bioactivity of all compounds has been investigated. Zorrimidazolone (2) showed a modest cytotoxic activity against C6 rat glioma cell line.

Zorrimidazolone, a bioactive alkaloid from the non-indigenous Mediterranean stolidobranch Polyandrocarpa zorritensis / Aiello, Anna; Fattorusso, Ernesto; Imperatore, Concetta; Irace, Carlo; Luciano, Paolo; Menna, Marialuisa; Santamaria, Rita; Vitalone, Rocco. - In: MARINE DRUGS. - ISSN 1660-3397. - 9:6(2011), pp. 1157-1165. [10.3390/md9061157]

Zorrimidazolone, a bioactive alkaloid from the non-indigenous Mediterranean stolidobranch Polyandrocarpa zorritensis

AIELLO, ANNA;FATTORUSSO, ERNESTO;IMPERATORE, CONCETTA;IRACE, CARLO;LUCIANO, PAOLO;MENNA, MARIALUISA;SANTAMARIA, RITA;VITALONE, ROCCO
2011

Abstract

Chemical analysis of the Mediterranean ascidian Polyandrocarpa zorritensis (Van Name 1931) resulted in the isolation of a series of molecules including two monoindole alkaloids, 3-indolylglyoxylic acid (3) and its methyl ester (4), 4-hydroxy-3-methoxyphenylglyoxylic acid methyl ester (1) and a new alkaloid we named zorrimidazolone (2). The structure of the novel compound 2 has been elucidated by spectroscopic analysis and bioactivity of all compounds has been investigated. Zorrimidazolone (2) showed a modest cytotoxic activity against C6 rat glioma cell line.
2011
Zorrimidazolone, a bioactive alkaloid from the non-indigenous Mediterranean stolidobranch Polyandrocarpa zorritensis / Aiello, Anna; Fattorusso, Ernesto; Imperatore, Concetta; Irace, Carlo; Luciano, Paolo; Menna, Marialuisa; Santamaria, Rita; Vitalone, Rocco. - In: MARINE DRUGS. - ISSN 1660-3397. - 9:6(2011), pp. 1157-1165. [10.3390/md9061157]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/393989
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