Abstract: We propose a method for achieving an optimal protocol of intermittent androgen suppression for the treatment of prostate cancer. Since the model that reproduces the dynamical behavior of the surrogate tumor marker, prostate specific antigen, is piecewise linear, we can obtain an analytical solution for the model. Based on this, we derive conditions for either stopping or delaying recurrent disease. The solution also provides a design principle for the most favorable schedule of treatment that minimizes the rate of expansion of the malignant cell population
Hybrid optimal scheduling for intermittent androgen suppression of prostate cancer / Y., Hirata; DI BERNARDO, Mario; N., Bruchovsky; K., Aihara. - In: CHAOS. - ISSN 1054-1500. - ELETTRONICO. - 20:4(2010), pp. -----. [10.1063/1.3526968]
Hybrid optimal scheduling for intermittent androgen suppression of prostate cancer
DI BERNARDO, MARIO;
2010
Abstract
Abstract: We propose a method for achieving an optimal protocol of intermittent androgen suppression for the treatment of prostate cancer. Since the model that reproduces the dynamical behavior of the surrogate tumor marker, prostate specific antigen, is piecewise linear, we can obtain an analytical solution for the model. Based on this, we derive conditions for either stopping or delaying recurrent disease. The solution also provides a design principle for the most favorable schedule of treatment that minimizes the rate of expansion of the malignant cell populationI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
