Mimochrome VI (MC-VI) is a synthetic heme peptide containing a helix-heme-helix sandwich motif designed to reproduce the catalytic activity of heme oxidases. The thermodynamics of Fe(III) to Fe(II) reduction and the kinetics of the electron-transfer process for MC-VI immobilized through hydrophobic interactions on a gold electrode coated with a nonpolar SAM of decane-1-thiol have been determined through cyclic voltammetry. Immobilization slightly affects the reduction potential of MC-VI, which under these conditions electrocatalytically turns over molecular oxygen. This work sets the premise for the exploitation of totally synthetic mimochrome-modified electrode surfaces for clinical and pharmaceutical biosensing.

Redox and electrocatalytic properties of mimochrome VI, a synthetic heme peptide adsorbed on gold / A., Ranieri; S., Monari; M., Sola; M., Borsari; G., Battistuzzi; Ringhieri, Paola; Nastri, Flavia; Pavone, Vincenzo; Lombardi, Angelina. - In: LANGMUIR. - ISSN 0743-7463. - STAMPA. - 26:23(2010), pp. 17831-17835. [10.1021/la103744x]

Redox and electrocatalytic properties of mimochrome VI, a synthetic heme peptide adsorbed on gold

RINGHIERI, PAOLA;NASTRI, FLAVIA;PAVONE, VINCENZO;LOMBARDI, ANGELINA
2010

Abstract

Mimochrome VI (MC-VI) is a synthetic heme peptide containing a helix-heme-helix sandwich motif designed to reproduce the catalytic activity of heme oxidases. The thermodynamics of Fe(III) to Fe(II) reduction and the kinetics of the electron-transfer process for MC-VI immobilized through hydrophobic interactions on a gold electrode coated with a nonpolar SAM of decane-1-thiol have been determined through cyclic voltammetry. Immobilization slightly affects the reduction potential of MC-VI, which under these conditions electrocatalytically turns over molecular oxygen. This work sets the premise for the exploitation of totally synthetic mimochrome-modified electrode surfaces for clinical and pharmaceutical biosensing.
2010
Redox and electrocatalytic properties of mimochrome VI, a synthetic heme peptide adsorbed on gold / A., Ranieri; S., Monari; M., Sola; M., Borsari; G., Battistuzzi; Ringhieri, Paola; Nastri, Flavia; Pavone, Vincenzo; Lombardi, Angelina. - In: LANGMUIR. - ISSN 0743-7463. - STAMPA. - 26:23(2010), pp. 17831-17835. [10.1021/la103744x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/388041
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