The study of the base-pairing properties of nucleic acids with sugar moieties in the backbone belonging to the l-series (b-l-DNA, b-l-RNA, and their analogs) are reviewed. The major structural factors underlying the formation of stable heterochiral complexes obtained by incorporation of modified nucleotides into natural duplexes, or by hybridization between homochiral strands of opposite sense of chirality are highlighted. In addition, the perspective use of l-nucleic acids as candidates for various therapeutic applications, or as tools for both synthetic biology and etiology-oriented investigations on the structure and stereochemistry of natural nucleic acids is discussed.

Exploring the role of chirality in nucleic acid recognition / D'Alonzo, Daniele; Guaragna, Annalisa; Palumbo, Giovanni. - In: CHEMISTRY & BIODIVERSITY. - ISSN 1612-1872. - 8:3(2011), pp. 373-413. [10.1002/cbdv.201000303]

Exploring the role of chirality in nucleic acid recognition

D'ALONZO, DANIELE;GUARAGNA, ANNALISA;PALUMBO, GIOVANNI
2011

Abstract

The study of the base-pairing properties of nucleic acids with sugar moieties in the backbone belonging to the l-series (b-l-DNA, b-l-RNA, and their analogs) are reviewed. The major structural factors underlying the formation of stable heterochiral complexes obtained by incorporation of modified nucleotides into natural duplexes, or by hybridization between homochiral strands of opposite sense of chirality are highlighted. In addition, the perspective use of l-nucleic acids as candidates for various therapeutic applications, or as tools for both synthetic biology and etiology-oriented investigations on the structure and stereochemistry of natural nucleic acids is discussed.
2011
Exploring the role of chirality in nucleic acid recognition / D'Alonzo, Daniele; Guaragna, Annalisa; Palumbo, Giovanni. - In: CHEMISTRY & BIODIVERSITY. - ISSN 1612-1872. - 8:3(2011), pp. 373-413. [10.1002/cbdv.201000303]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/382349
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