Herein, we wish to report new data that DHICA possesses ef???cient hydrogen donor properties, Fe(III) reducing power and OH radical-scavenging ef???ciency in Fenton processes and show for the ???rst time that the main circulating DHICA metabolite, 6H5MICA, exhibits an antioxidant activity comparable to that of DHICA. We propose that DHICA and 6H5MICA may provide a missing key toward an understanding of the physiological signi???- cance of Dct and melanogenesis beyond the mere provision of a pigment.
Is DHICA the key to dopachrome tautomerase and melanocyte functions? / Panzella, Lucia; Napolitano, Alessandra; D'Ischia, Marco. - In: PIGMENT CELL & MELANOMA RESEARCH. - ISSN 1755-1471. - 24:1(2011), pp. 248-249. [10.1111/j.1755-148X.2010.00771.x]
Is DHICA the key to dopachrome tautomerase and melanocyte functions?
PANZELLA, LUCIA;NAPOLITANO, ALESSANDRA;D'ISCHIA, MARCO
2011
Abstract
Herein, we wish to report new data that DHICA possesses ef???cient hydrogen donor properties, Fe(III) reducing power and OH radical-scavenging ef???ciency in Fenton processes and show for the ???rst time that the main circulating DHICA metabolite, 6H5MICA, exhibits an antioxidant activity comparable to that of DHICA. We propose that DHICA and 6H5MICA may provide a missing key toward an understanding of the physiological signi???- cance of Dct and melanogenesis beyond the mere provision of a pigment.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
