Two indole alkaloids, phidianidines A (1) and B (2), exhibiting an uncommon 1,2,4-oxadiazole ring linked to the indole system, have been isolated from the marine opisthobranch mollusk Phidiana militaris. The structures of the two metabolites have been elucidated by spectroscopic techniques. Phidianidines exhibit high cytotoxicity against tumor and nontumor mammalian cell lines in in vitro assays.

Structures and cytotoxicity of phidianidines A and B: firstfinding of 1,2,4 oxadiazole system in a marine naturalproduct / Carbone, M.; Li, Y.; Irace, Carlo; Mollo, E.; Castelluccio, F.; Di Pascale, A.; Cimino, G.; Santamaria, Rita; Guo, Y. W.; Gavagnin, M.. - In: ORGANIC LETTERS. - ISSN 1523-7060. - 13:10(2011), pp. 2516-2519. [10.1021/ol200234r]

Structures and cytotoxicity of phidianidines A and B: firstfinding of 1,2,4 oxadiazole system in a marine naturalproduct.

IRACE, CARLO;SANTAMARIA, RITA;
2011

Abstract

Two indole alkaloids, phidianidines A (1) and B (2), exhibiting an uncommon 1,2,4-oxadiazole ring linked to the indole system, have been isolated from the marine opisthobranch mollusk Phidiana militaris. The structures of the two metabolites have been elucidated by spectroscopic techniques. Phidianidines exhibit high cytotoxicity against tumor and nontumor mammalian cell lines in in vitro assays.
2011
Structures and cytotoxicity of phidianidines A and B: firstfinding of 1,2,4 oxadiazole system in a marine naturalproduct / Carbone, M.; Li, Y.; Irace, Carlo; Mollo, E.; Castelluccio, F.; Di Pascale, A.; Cimino, G.; Santamaria, Rita; Guo, Y. W.; Gavagnin, M.. - In: ORGANIC LETTERS. - ISSN 1523-7060. - 13:10(2011), pp. 2516-2519. [10.1021/ol200234r]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/381677
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