The invention relates to a fusion protein, designated as TAT-RH, comprising a first segment consisting of the minimal sequence of the HIV-TAT transduction domain and a second segment consisting of the RH region of the GRK5 kinase. Advantageously, the TAT- RH fusion protein is capable of penetrating into an eukaryotic cell without the help provided by vectors, and is capable of increasing cell apoptosis. These properties make the TAT-RH fusion protein according to the invention particularly suitable as an anti-tumor medicament. The invention further describes the nucleic acid sequence encoding for the TAT-RH fusion protein, a host cell transformed with the nucleic acid encoding for TAT- RH, as well as a method for the manufacture of TAT-RH by recombinant means.

A FUSION PROTEIN HAVING ANTITUMOR ACTIVITY

IACCARINO, GUIDO;TRIMARCO, BRUNO;SORRIENTO D.
2009

Abstract

The invention relates to a fusion protein, designated as TAT-RH, comprising a first segment consisting of the minimal sequence of the HIV-TAT transduction domain and a second segment consisting of the RH region of the GRK5 kinase. Advantageously, the TAT- RH fusion protein is capable of penetrating into an eukaryotic cell without the help provided by vectors, and is capable of increasing cell apoptosis. These properties make the TAT-RH fusion protein according to the invention particularly suitable as an anti-tumor medicament. The invention further describes the nucleic acid sequence encoding for the TAT-RH fusion protein, a host cell transformed with the nucleic acid encoding for TAT- RH, as well as a method for the manufacture of TAT-RH by recombinant means.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/378376
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