Trans-AT polyketide synthases (PKSs) are a recently discovered group of biosynthetic enzymes present in many bacteria. A strategy for the prediction of natural product structures from trans-AT PKS sequences was demonstrated to be a useful approach for the targeted isolation of bioactive polyketides from chemically poorly studied prokaryotic phyla, as exemplified by the elansolid-type antibiotics.
Genome Mining Reveals trans-AT Polyketide Synthase Directed Antibiotic Biosynthesis in the Bacterial Phylum Bacteroidetes / Teta, Roberta; M., Gurgui; E. J. N., Helfrich; S., Künne; Schneider, A.; G., Van Echten Deckert; Mangoni, Alfonso; J., Piel. - In: CHEMBIOCHEM. - ISSN 1439-4227. - STAMPA. - 11:(2010), pp. 2506-2512. [10.1002/cbic.201000542]
Genome Mining Reveals trans-AT Polyketide Synthase Directed Antibiotic Biosynthesis in the Bacterial Phylum Bacteroidetes
TETA, ROBERTAPrimo
;MANGONI, ALFONSO;
2010
Abstract
Trans-AT polyketide synthases (PKSs) are a recently discovered group of biosynthetic enzymes present in many bacteria. A strategy for the prediction of natural product structures from trans-AT PKS sequences was demonstrated to be a useful approach for the targeted isolation of bioactive polyketides from chemically poorly studied prokaryotic phyla, as exemplified by the elansolid-type antibiotics.| File | Dimensione | Formato | |
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