Terpioside B, a unique glycolipid containing two fucose residues in the furanose form in its pentasaccharide chain, was isolated from the marine sponge Terpios sp. Its complete stereostructure was solved by interpretation of mass spectrometric and NMR data along with CD and GG-MS analyses of its degradation products. Terpioside B is a potent inhibitor against LPS-induced NO release, and is considerably more active than simpler glycosphingolipids such as terpioside A and monoglucosylceramide.
Glycolipids from sponges. 22. Terpioside B, a difucosyl GSL from the marine sponge Terpios sp. is a potent inhibitor of NO release / Costantino, Valeria; Fattorusso, Ernesto; Mangoni, Alfonso; Teta, Roberta; Panza, Elisabetta; Ianaro, Angela. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - STAMPA. - 18:(2010), pp. 5310-5315. [10.1016/j.bmc.2010.05.048]
Glycolipids from sponges. 22. Terpioside B, a difucosyl GSL from the marine sponge Terpios sp. is a potent inhibitor of NO release
COSTANTINO, VALERIA;FATTORUSSO, ERNESTO;MANGONI, ALFONSO;TETA, ROBERTA;PANZA, ELISABETTA;IANARO, ANGELA
2010
Abstract
Terpioside B, a unique glycolipid containing two fucose residues in the furanose form in its pentasaccharide chain, was isolated from the marine sponge Terpios sp. Its complete stereostructure was solved by interpretation of mass spectrometric and NMR data along with CD and GG-MS analyses of its degradation products. Terpioside B is a potent inhibitor against LPS-induced NO release, and is considerably more active than simpler glycosphingolipids such as terpioside A and monoglucosylceramide.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
