Aim of this study was to investigate the anti-HBs antibody persistence and immune memory to hepatitis B virus in adult celiacs vaccinated as adolescents and the effect of a booster administration in non-protected individuals. Eleven years after primary vaccination, the proportion of vaccinees with titres ≥ 10 mIU/ml and antibody geometric mean concentrations (GMCs) were lower among celiac patients than among controls (68.6% vs 91.7%, p<0.01; GMCs 29.38 mIU/ml vs 250.6 mIU/ml, p<0.001). Participants with anti-HBs below 10 mIU/ml received a booster dose and were retested 2 weeks later to assess the anamnestic response. Post-booster anti-HBs levels were still <10 mIU/ml in 71.4% celiacs and 25% controls (p<0.01). Our findings indicate that the prevalence of seroprotective levels of anti-HBs detected eleven years after primary immunization as well as the frequency of response to a booster dose of vaccine are lower in celiac patients compared to healthy controls.

Long-term antibody persistence and immune memory to hepatitis B virus in adult celiac patients vaccinated as adolescents / Zingone, F; Morisco, Filomena; Zanetti, A; Romanò, L; Portella, Giuseppe; Capone, P; Andreozzi, P; Tortora, R; Ciacci, Carolina. - In: VACCINE. - ISSN 0264-410X. - STAMPA. - 29:5(2011), pp. 1005-1008. [10.1016/j.vaccine.2010.11.060]

Long-term antibody persistence and immune memory to hepatitis B virus in adult celiac patients vaccinated as adolescents.

MORISCO, FILOMENA;PORTELLA, GIUSEPPE;CIACCI, CAROLINA
2011

Abstract

Aim of this study was to investigate the anti-HBs antibody persistence and immune memory to hepatitis B virus in adult celiacs vaccinated as adolescents and the effect of a booster administration in non-protected individuals. Eleven years after primary vaccination, the proportion of vaccinees with titres ≥ 10 mIU/ml and antibody geometric mean concentrations (GMCs) were lower among celiac patients than among controls (68.6% vs 91.7%, p<0.01; GMCs 29.38 mIU/ml vs 250.6 mIU/ml, p<0.001). Participants with anti-HBs below 10 mIU/ml received a booster dose and were retested 2 weeks later to assess the anamnestic response. Post-booster anti-HBs levels were still <10 mIU/ml in 71.4% celiacs and 25% controls (p<0.01). Our findings indicate that the prevalence of seroprotective levels of anti-HBs detected eleven years after primary immunization as well as the frequency of response to a booster dose of vaccine are lower in celiac patients compared to healthy controls.
2011
Long-term antibody persistence and immune memory to hepatitis B virus in adult celiac patients vaccinated as adolescents / Zingone, F; Morisco, Filomena; Zanetti, A; Romanò, L; Portella, Giuseppe; Capone, P; Andreozzi, P; Tortora, R; Ciacci, Carolina. - In: VACCINE. - ISSN 0264-410X. - STAMPA. - 29:5(2011), pp. 1005-1008. [10.1016/j.vaccine.2010.11.060]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/375065
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