A straightforward procedure for the preparation of nucleoside analogue 1 and its regioisomer 2 containing a dihydro-1,4-dithiin as sugar moiety has been accomplished in four steps by our readily available heterocyclic system 5. Nucleobase insertion was carried out by direct addition of N4-acetylcytosine to sulfoxide derivatives via Pummerer-type glycosidation reaction.

Synthesis of 2,3-dihydro-1,4-dithiinyl nucleosides via pummerer-type glycosidation

PAOLELLA, CONCETTA;D’Alonzo D.;GUARAGNA, ANNALISA
;
CERMOLA, FLAVIO;PALUMBO, GIOVANNI
2010

Abstract

A straightforward procedure for the preparation of nucleoside analogue 1 and its regioisomer 2 containing a dihydro-1,4-dithiin as sugar moiety has been accomplished in four steps by our readily available heterocyclic system 5. Nucleobase insertion was carried out by direct addition of N4-acetylcytosine to sulfoxide derivatives via Pummerer-type glycosidation reaction.
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Tetrahedron Letters 51 (2010) 6060–6063.pdf

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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11588/374299
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