Eight known and two new triterpenoid derivatives, neemfruitins A (9) and B (10), have been isolated from the fruits of neem, Azadirachta indica, a traditional antimalarial plant used by Asian and African populations. In vitro antiplasmodial tests evidenced a significant activity of the known gedunin and azadirone and the new neemfruitin A and provided useful information about the structure-antimalarial activity relationships in the limonoid class.
Antiplasmodial triterpenoids from the fruits of neem, Azadirachta indica / Chianese, Giuseppina; S. R., Yerbanga; L., Lucantoni; A., Habluetzel; N., Basilico; D., Taramelli; Fattorusso, Ernesto; TAGLIALATELA SCAFATI, Orazio. - In: JOURNAL OF NATURAL PRODUCTS. - ISSN 0163-3864. - STAMPA. - 73:(2010), pp. 1448-1452. [10.1021/np100325q]
Antiplasmodial triterpenoids from the fruits of neem, Azadirachta indica
CHIANESE, GIUSEPPINA;FATTORUSSO, ERNESTO;TAGLIALATELA SCAFATI, ORAZIO
2010
Abstract
Eight known and two new triterpenoid derivatives, neemfruitins A (9) and B (10), have been isolated from the fruits of neem, Azadirachta indica, a traditional antimalarial plant used by Asian and African populations. In vitro antiplasmodial tests evidenced a significant activity of the known gedunin and azadirone and the new neemfruitin A and provided useful information about the structure-antimalarial activity relationships in the limonoid class.| File | Dimensione | Formato | |
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