Differently from chronic hepatitis C, factors associated with hepatic steatosis in children with chronic hepatitis B are not clearly elucidated. Objective Aim of this study was to investigate prevalence of steatosis at liver biopsy in HBV-infected children. Study design A retrospective study including 56 children with chronic hepatitis B undergoing liver biopsy at median age of 8.1 years. In all patients demographic, anthropometric, clinical and laboratory data were evaluated at the time of liver biopsy. Results Steatosis was present in 2 (4%) children. BMI was significantly higher in 2 patients with steatosis compared with those without steatosis. Demographic, biochemical and virological parameters did not differ between children with and those without steatosis. Conclusions Liver steatosis in HBV-infected children seems to be related to obesity and metabolic factors rather than to viral factors. Detection of steatosis in non-obese children with HBV infection requires a careful investigation to rule out other causes of fatty liver.

Hepatic steatosis is uncommon in children with chronic hepatitis B

GIANNATTASIO, ANTONIETTA;CIRILLO, FRANCESCO;TERLIZZI, VITO;LICCARDO, DANIELA;VECCHIONE, RAFFAELA;IORIO, RAFFAELE
2009

Abstract

Differently from chronic hepatitis C, factors associated with hepatic steatosis in children with chronic hepatitis B are not clearly elucidated. Objective Aim of this study was to investigate prevalence of steatosis at liver biopsy in HBV-infected children. Study design A retrospective study including 56 children with chronic hepatitis B undergoing liver biopsy at median age of 8.1 years. In all patients demographic, anthropometric, clinical and laboratory data were evaluated at the time of liver biopsy. Results Steatosis was present in 2 (4%) children. BMI was significantly higher in 2 patients with steatosis compared with those without steatosis. Demographic, biochemical and virological parameters did not differ between children with and those without steatosis. Conclusions Liver steatosis in HBV-infected children seems to be related to obesity and metabolic factors rather than to viral factors. Detection of steatosis in non-obese children with HBV infection requires a careful investigation to rule out other causes of fatty liver.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/369090
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