Chemical investigation of the Mediterranean ascidian Ciona edwardsii has been performed, leading to the isolation of two halogenated compounds: a new tyrosine-iodinated derivative iodocionin (1) and the relevant brominated analogue (2), previously isolated from a Caribbean sponge. The structure of the new compound 1 has been assigned on the basis of spectroscopic analysis.Both compounds were tested for cytotoxicity in vitro against two different cancer cell lines, L5178Y (mouse lymphoma) and PC-12 (rat pheochromocytoma). Iodocionin was shown to possess significant and selective activity against lymphoma cells with an IC50 of 7.75 μg/mL.
Iodocionin, a cytotoxic iodinated metabolite from the Mediterranean ascidian Ciona edwardsii / Aiello, Anna; Fattorusso, Ernesto; Imperatore, Concetta; Menna, Marialuisa; W. E. G., Muller. - In: MARINE DRUGS. - ISSN 1660-3397. - 8:2(2010), pp. 285-291. [10.3390/md8020285]
Iodocionin, a cytotoxic iodinated metabolite from the Mediterranean ascidian Ciona edwardsii.
AIELLO, ANNA;FATTORUSSO, ERNESTO;IMPERATORE, CONCETTA;MENNA, MARIALUISA;
2010
Abstract
Chemical investigation of the Mediterranean ascidian Ciona edwardsii has been performed, leading to the isolation of two halogenated compounds: a new tyrosine-iodinated derivative iodocionin (1) and the relevant brominated analogue (2), previously isolated from a Caribbean sponge. The structure of the new compound 1 has been assigned on the basis of spectroscopic analysis.Both compounds were tested for cytotoxicity in vitro against two different cancer cell lines, L5178Y (mouse lymphoma) and PC-12 (rat pheochromocytoma). Iodocionin was shown to possess significant and selective activity against lymphoma cells with an IC50 of 7.75 μg/mL.File | Dimensione | Formato | |
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