Hepatitis B surface antigen (HBsAg) is considered the best marker for the diagnosis of hepatitis B virus (HBV) infection. Mutations of the s gene involving amino acid substitutions within the a determinant could affect the sensitivity of diagnostic tests. In the present study, HBsAg mutants were detected in 3 immunocompromised patients, previously found to be HBsAg negative and anti-HBs positive. All patients had high levels of HBV-DNA, whereas HBsAg tests gave discordant results. Immunosuppression can cause viral reactivation of occult HBV infection in these patients and favour the selection of HBsAg a determinant mutants. 2010 S. Karger AG, Basel.

Immunocompromised patients with HBsAg a determinant mutants: comparison of HBsAg diagnostic assays.

;ORLANDO, RAFFAELE;TOSONE, GRAZIA;GENOVESE, ARTURO;SPADARO, GIUSEPPE;D'ORIO, CONCETTA;PORTELLA, GIUSEPPE
2010

Abstract

Hepatitis B surface antigen (HBsAg) is considered the best marker for the diagnosis of hepatitis B virus (HBV) infection. Mutations of the s gene involving amino acid substitutions within the a determinant could affect the sensitivity of diagnostic tests. In the present study, HBsAg mutants were detected in 3 immunocompromised patients, previously found to be HBsAg negative and anti-HBs positive. All patients had high levels of HBV-DNA, whereas HBsAg tests gave discordant results. Immunosuppression can cause viral reactivation of occult HBV infection in these patients and favour the selection of HBsAg a determinant mutants. 2010 S. Karger AG, Basel.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11588/364303
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