BACKGROUND: Bacteria that belong to the genus Sphingobacterium are Gram-negative, non-fermentative bacilli, ubiquitous in nature and rarely involved in human infections. The aims of this study were to evaluate the epidemiology of infection by Sphingobacterium in a cohort of patients affected by Cystic Fibrosis (CF), the antibiotic susceptibility and the DNA fingerprinting of the isolated strains and to analyze some clinical outcomes of the infected patients. FINDINGS: Between January 2006 and June 2008, patients (n = 332) attending the Regional CF Unit in Naples, Italy, were enrolled. Sputum samples were processed for microscopic, cultural, phenotypic identification and antibiotic susceptibility testing. DNA fingerprinting was performed by pulsed-field gel electrophoresis (PFGE). A total of 21 strains of Sphingobacterium were isolated from 7 patients (13 of S. spiritovorum, 8 of S. multivorum). S. multivorum isolates were more resistant than those of S. spiritovorum. PFGE profiles were in general heterogeneous, which suggested independent circulation. CONCLUSIONS: This is the first Italian report about respiratory tract infections by Sphingobacterium in CF patients. In our cohort, these infections were not associated with a deterioration of pulmonary function during the follow-up period. Although the exact role of this microorganism in CF lung disease is unknown and the number of infected patients was small, this study could represent an important starting-point for understanding the epidemiology and the possible pathogenic role of Sphingobacterium in CF patients.

Sphingobacterium respiratory tract infection in patients with cystic fibrosis / Lambiase, A.; Rossano, Fabio; DEL PEZZO, Mariassunta; Raia, Valeria; Sepe, A.; DE GREGORIO, Fabiola; Catania, MARIA ROSARIA. - In: BMC RESEARCH NOTES. - ISSN 1756-0500. - ELETTRONICO. - 2:(2009), pp. 1-5.

Sphingobacterium respiratory tract infection in patients with cystic fibrosis.

ROSSANO, FABIO;DEL PEZZO, MARIASSUNTA;RAIA, VALERIA;DE GREGORIO, FABIOLA;CATANIA, MARIA ROSARIA
2009

Abstract

BACKGROUND: Bacteria that belong to the genus Sphingobacterium are Gram-negative, non-fermentative bacilli, ubiquitous in nature and rarely involved in human infections. The aims of this study were to evaluate the epidemiology of infection by Sphingobacterium in a cohort of patients affected by Cystic Fibrosis (CF), the antibiotic susceptibility and the DNA fingerprinting of the isolated strains and to analyze some clinical outcomes of the infected patients. FINDINGS: Between January 2006 and June 2008, patients (n = 332) attending the Regional CF Unit in Naples, Italy, were enrolled. Sputum samples were processed for microscopic, cultural, phenotypic identification and antibiotic susceptibility testing. DNA fingerprinting was performed by pulsed-field gel electrophoresis (PFGE). A total of 21 strains of Sphingobacterium were isolated from 7 patients (13 of S. spiritovorum, 8 of S. multivorum). S. multivorum isolates were more resistant than those of S. spiritovorum. PFGE profiles were in general heterogeneous, which suggested independent circulation. CONCLUSIONS: This is the first Italian report about respiratory tract infections by Sphingobacterium in CF patients. In our cohort, these infections were not associated with a deterioration of pulmonary function during the follow-up period. Although the exact role of this microorganism in CF lung disease is unknown and the number of infected patients was small, this study could represent an important starting-point for understanding the epidemiology and the possible pathogenic role of Sphingobacterium in CF patients.
2009
Sphingobacterium respiratory tract infection in patients with cystic fibrosis / Lambiase, A.; Rossano, Fabio; DEL PEZZO, Mariassunta; Raia, Valeria; Sepe, A.; DE GREGORIO, Fabiola; Catania, MARIA ROSARIA. - In: BMC RESEARCH NOTES. - ISSN 1756-0500. - ELETTRONICO. - 2:(2009), pp. 1-5.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/363344
Citazioni
  • ???jsp.display-item.citation.pmc??? 17
  • Scopus 48
  • ???jsp.display-item.citation.isi??? ND
social impact