OBJECTIVES: The aim of this study is to evaluate general practitioners’ prescription (GPs) of different Proton Pump Inhibitors (PPIs) in the period between 2005 to 2008. METHODS: Analysis has been performed on a database of 99 medical practitioners that have managed an average of 150.000 inhabitants. We evaluate the PPIs prescriptions from January 2005 to December 2008. Evaluations performed are the following:1) PPI prescription (total and separately for lansoprazole, esomeprazole, pantoprazole,rabeprazole, and omeprazole); 2) prevalence of the reimbursement purpose (Gastroprotection—G; Acid-Related Disease—ARD); 3) prevalence of patients with ARD categorized on the basis of PPI prescriptions as drugs box/year (1–3 short treatment— ST; 4–11 long treatment—LT; >12 very long treatment—VLT). Data were expressed as Compound Annual Growth Rate (CAGR). RESULTS: The total volume of PPI’s prescribing increased progressively over the 4 years (CAGR +15%). The growth for each molecule was: L +42%; E +11%; P +16; R +3%; O 1%. The reimbursement purpose was significantly higher for G (CAGR +41%) than for ARD (CAGR +6%; p < 0.01). We found an increase of ARD patients with VLT with a significant highest CAGR (ST +3.9%, LT +4.8%, VLT +7.4%; p < 0.01). PPI prescription showed a highest CAGR for L in all patients (27%), while the lowest one was for O in VLT patients (-9%). CONCLUSIONS: Generic PPIs has unexpectedly increased the prescription of whole drug class during the period 2005–2008. We observed a marked increase in a very long duration PPI treatment for ARD that caused a relevant resource consumption. Our data suggest that the appropriateness of PPI prescription after generic PPI introduction should be carefully monitored to distinguish between costeffective from cost-ineffective PPI treatment.

Influence of generic drugs on proton pump inhibitor prescription in primary care / Cammarota, Simona; De Portu, S; Citarella, A; Menditto, Enrica; Cuomo, Rosario. - In: VALUE IN HEALTH. - ISSN 1098-3015. - ELETTRONICO. - 12:(2009), pp. A222-A222. [10.1016/S1098-3015(10)74085-7]

Influence of generic drugs on proton pump inhibitor prescription in primary care.

CAMMAROTA, SIMONA;MENDITTO, ENRICA;CUOMO, ROSARIO
2009

Abstract

OBJECTIVES: The aim of this study is to evaluate general practitioners’ prescription (GPs) of different Proton Pump Inhibitors (PPIs) in the period between 2005 to 2008. METHODS: Analysis has been performed on a database of 99 medical practitioners that have managed an average of 150.000 inhabitants. We evaluate the PPIs prescriptions from January 2005 to December 2008. Evaluations performed are the following:1) PPI prescription (total and separately for lansoprazole, esomeprazole, pantoprazole,rabeprazole, and omeprazole); 2) prevalence of the reimbursement purpose (Gastroprotection—G; Acid-Related Disease—ARD); 3) prevalence of patients with ARD categorized on the basis of PPI prescriptions as drugs box/year (1–3 short treatment— ST; 4–11 long treatment—LT; >12 very long treatment—VLT). Data were expressed as Compound Annual Growth Rate (CAGR). RESULTS: The total volume of PPI’s prescribing increased progressively over the 4 years (CAGR +15%). The growth for each molecule was: L +42%; E +11%; P +16; R +3%; O 1%. The reimbursement purpose was significantly higher for G (CAGR +41%) than for ARD (CAGR +6%; p < 0.01). We found an increase of ARD patients with VLT with a significant highest CAGR (ST +3.9%, LT +4.8%, VLT +7.4%; p < 0.01). PPI prescription showed a highest CAGR for L in all patients (27%), while the lowest one was for O in VLT patients (-9%). CONCLUSIONS: Generic PPIs has unexpectedly increased the prescription of whole drug class during the period 2005–2008. We observed a marked increase in a very long duration PPI treatment for ARD that caused a relevant resource consumption. Our data suggest that the appropriateness of PPI prescription after generic PPI introduction should be carefully monitored to distinguish between costeffective from cost-ineffective PPI treatment.
2009
Influence of generic drugs on proton pump inhibitor prescription in primary care / Cammarota, Simona; De Portu, S; Citarella, A; Menditto, Enrica; Cuomo, Rosario. - In: VALUE IN HEALTH. - ISSN 1098-3015. - ELETTRONICO. - 12:(2009), pp. A222-A222. [10.1016/S1098-3015(10)74085-7]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/361435
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