Amyloidlike proteins form highly organized aggregates, such as fibrils and plaques, preceded by the assem- bly of a wide range of unstructured oligomers and protofibrils. Despite their importance in a number of human neurodegenerative diseases, a comprehensive understanding of their kinetics and thermodynamics is still miss- ing. We investigate, by computer simulations, a realistic model of amyloid molecules interacting via the experimentally determined Derjaguin-Landau-Verwey-Overbeek potential and derive its phase diagram. We show that fibrils and plaques, along with their precursors, correspond to different equilibrium and metastable thermodynamics phases and discuss the dynamical mechanisms leading to the nucleation and self-assembly of large scale structures.

Aggregation of brils and plaques in amyloid molecular systems

NICODEMI, MARIO;DE CANDIA, ANTONIO;CONIGLIO, ANTONIO
2009

Abstract

Amyloidlike proteins form highly organized aggregates, such as fibrils and plaques, preceded by the assem- bly of a wide range of unstructured oligomers and protofibrils. Despite their importance in a number of human neurodegenerative diseases, a comprehensive understanding of their kinetics and thermodynamics is still miss- ing. We investigate, by computer simulations, a realistic model of amyloid molecules interacting via the experimentally determined Derjaguin-Landau-Verwey-Overbeek potential and derive its phase diagram. We show that fibrils and plaques, along with their precursors, correspond to different equilibrium and metastable thermodynamics phases and discuss the dynamical mechanisms leading to the nucleation and self-assembly of large scale structures.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/358729
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