Nine new cyclodepsipeptides, homophymines B–E (2–5) and A1–E1 (1a–5a), were isolated from the polar extracts of the sponge Homophymia sp. The new structures, featuring new polyketide-derived end groups, were determined by interpretation of NMR and MS data. The configurations of the new end groups was secured by the application of J-based configurational analysis. Homophymines displayed very potent antiproliferative activity (IC50 in the nM range) against a panel of human cancer cell lines.
Homophymines B-E and A1-E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp / Zampella, Angela; Sepe, Valentina; Bellotta, Filomena; Luciano, Paolo; D'Auria, MARIA VALERIA; Cresteil, Thierry; Debitus, Cecile; Petek, Sylvain; Poupat, Christiane; Ahond, A. l. a. i. n.. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - STAMPA. - 7:19(2009), pp. 4037-4044. [10.1039/b910015f]
Homophymines B-E and A1-E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp.
ZAMPELLA, ANGELA;SEPE, VALENTINA;LUCIANO, PAOLO;D'AURIA, MARIA VALERIA;
2009
Abstract
Nine new cyclodepsipeptides, homophymines B–E (2–5) and A1–E1 (1a–5a), were isolated from the polar extracts of the sponge Homophymia sp. The new structures, featuring new polyketide-derived end groups, were determined by interpretation of NMR and MS data. The configurations of the new end groups was secured by the application of J-based configurational analysis. Homophymines displayed very potent antiproliferative activity (IC50 in the nM range) against a panel of human cancer cell lines.| File | Dimensione | Formato | |
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