Small-cell lung cancer and necrolytic migratory erythema.

A 73-year-old man presented with persistent and progressive muco-cutaneous lesions. The oral mucosa showed bullous/erosive mucositis with several areas having lichenoid clinical features. His body, including the genital area, was covered in progressive purplish confluent erythemato-papulous scaling and crusting lesions with a keratotic surface. The histology from skin/oral mucosa revealed features consistent with necrolytic migratory erythema (NME). A total body computed tomography (CT) revealed the presence of a 40 mm-diameter ovoidal mass in the upper lobe of the right lung.An ultrasound-guided needle biopsy of the lung revealed a small-cell lung cancer. A diagnosis of non-glucagonoma-associated NME was made. The patient died two months later. This is the first case of NME associated with small-cell lung cancer, exhibiting oral bullous/erosive mucositis and lichenoid features