Cytosolic aspartate aminotransferase (EC 2.6.1.1) from ox heart has been fully characterized; the most significant results have been reviewed. An investigation is now in progress to establish structural and evolutionary relationships between this enzyme and the homologous one from pig heart, whose complete primary structure has been reported. A more complete picture from an evolutionary point of view should also arise from a comparison of the mitochondrial enzymes. In fact the primary structure of the mitochondrial porcine enzyme has been reported. Structural investigations on cytosolic and mitochondrial chicken aspartate aminotransferases are being pursued. Therefore we have undertaken the purification and characterization of mitochondrial bovine aspartate aminotransferase. Preliminary sequence and crystallographic data are reported here.

Mitochondrial bovine aspartate aminotransferase. Preliminary sequence and crystallographic data.

MARINO, GENNARO;MAZZARELLA, LELIO;PUCCI, PIETRO;SANNIA, GIOVANNI
1979

Abstract

Cytosolic aspartate aminotransferase (EC 2.6.1.1) from ox heart has been fully characterized; the most significant results have been reviewed. An investigation is now in progress to establish structural and evolutionary relationships between this enzyme and the homologous one from pig heart, whose complete primary structure has been reported. A more complete picture from an evolutionary point of view should also arise from a comparison of the mitochondrial enzymes. In fact the primary structure of the mitochondrial porcine enzyme has been reported. Structural investigations on cytosolic and mitochondrial chicken aspartate aminotransferases are being pursued. Therefore we have undertaken the purification and characterization of mitochondrial bovine aspartate aminotransferase. Preliminary sequence and crystallographic data are reported here.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/356116
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