Laccases (benzenediol:oxygen oxidoreductases, EC 1.10.3.2) are blue multicopper oxidases that catalyze the oxidation of an array of aromatic substrates concomitantly with the reduction of molecular oxygen to water. In fungi, laccases carry out a variety of physiological roles during their life cycle. These enzymes are being increasingly evaluated for a variety of biotechnological applications due to their broad substrate range. In this review, the most recent studies on laccase structural features and catalytic mechanisms along with analyses of their expression are reported and examined with the aim of contributing to the discussion on their structure–function relationships. Attention has also been paid to the properties of enzymes endowed with unique characteristics and to fungal laccase multigene families and their organization.

Laccase: a neverending story / Giardina, Paola; Faraco, Vincenza; Pezzella, C.; Piscitelli, Alessandra; Vanhulle, S.; Sannia, Giovanni. - In: CELLULAR AND MOLECULAR LIFE SCIENCES. - ISSN 1420-682X. - STAMPA. - 67:(2010), pp. 369-385. [10.1007/s00018-009-0169-1]

Laccase: a neverending story

GIARDINA, PAOLA;FARACO, VINCENZA;Pezzella C.;PISCITELLI, ALESSANDRA;SANNIA, GIOVANNI
2010

Abstract

Laccases (benzenediol:oxygen oxidoreductases, EC 1.10.3.2) are blue multicopper oxidases that catalyze the oxidation of an array of aromatic substrates concomitantly with the reduction of molecular oxygen to water. In fungi, laccases carry out a variety of physiological roles during their life cycle. These enzymes are being increasingly evaluated for a variety of biotechnological applications due to their broad substrate range. In this review, the most recent studies on laccase structural features and catalytic mechanisms along with analyses of their expression are reported and examined with the aim of contributing to the discussion on their structure–function relationships. Attention has also been paid to the properties of enzymes endowed with unique characteristics and to fungal laccase multigene families and their organization.
2010
Laccase: a neverending story / Giardina, Paola; Faraco, Vincenza; Pezzella, C.; Piscitelli, Alessandra; Vanhulle, S.; Sannia, Giovanni. - In: CELLULAR AND MOLECULAR LIFE SCIENCES. - ISSN 1420-682X. - STAMPA. - 67:(2010), pp. 369-385. [10.1007/s00018-009-0169-1]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/355560
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