Dimethylsulfoxide (DMSO) is an organic compound widely used as solvent in biological studies and as vehicle for drug administration. DMSO has been shown to possess several biological effects, including antioxidant, anti-inflammatory, antinociceptive and it has been proposed to be therapeutic in several disorders, such as gastrointestinal diseases, rheumatologic diseases and for the treatment of several manifestations of amyloidosis. To better define the biological profile of DMSO, we investigated its effect on an in vivo model of acute myocardial infarction in rats, caused by left anterior descending coronary artery (LAD) ligation. Our results show that rat pre-treatment with DMSO (500 µl/ kg ip.) for three consecutive days before LAD ligation significantly (P < 0.05) reduced cardiac damage from 18.75 ± 4.88 % (n= 12) to 4.46 ± 2.01 % (n=8); serum levels of troponin I, from 29.35 ± 12.32 ng/ml (n=8) to 2.95 ± 1.32 ng/ml (n=4) and serum levels of myoglobin, from 46.86 ± 10.35 ng/ml (n=7) to 13.75 ± 0.85 ng/ml (n=4). Our data demonstrate that DMSO has a protective effect in a model of acute myocardial infarction in rats.

Protective effect of dimethylsulfoxide on acute myocardial infarction in rats

PARISI, ANTONIO;ALFIERI, ALESSIO;MAZZELLA, Marialuisa;MASCOLO, NICOLA DOMENICO C. FERDINANDO;CICALA, CARLA
Ultimo
2010

Abstract

Dimethylsulfoxide (DMSO) is an organic compound widely used as solvent in biological studies and as vehicle for drug administration. DMSO has been shown to possess several biological effects, including antioxidant, anti-inflammatory, antinociceptive and it has been proposed to be therapeutic in several disorders, such as gastrointestinal diseases, rheumatologic diseases and for the treatment of several manifestations of amyloidosis. To better define the biological profile of DMSO, we investigated its effect on an in vivo model of acute myocardial infarction in rats, caused by left anterior descending coronary artery (LAD) ligation. Our results show that rat pre-treatment with DMSO (500 µl/ kg ip.) for three consecutive days before LAD ligation significantly (P < 0.05) reduced cardiac damage from 18.75 ± 4.88 % (n= 12) to 4.46 ± 2.01 % (n=8); serum levels of troponin I, from 29.35 ± 12.32 ng/ml (n=8) to 2.95 ± 1.32 ng/ml (n=4) and serum levels of myoglobin, from 46.86 ± 10.35 ng/ml (n=7) to 13.75 ± 0.85 ng/ml (n=4). Our data demonstrate that DMSO has a protective effect in a model of acute myocardial infarction in rats.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/354943
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