The in vivo early detection of subcutaneous human tumors implanted in small animals was studied by laser-induced fluorescence reflectance imaging (FRI), with a hematoporphyrin (HP) compound as an exogenous optical contrast agent. Tumor detection was shown to be possible just 3 days after the inoculation of tumor cells, when tumors were neither visible nor palpable. However, this detection capability is limited to a temporal window of approximately 100 h from HP administration and to a low optical contrast of the tumor (<2).

Hematoporphyrin-mediated fluorescence reflectance imaging: application to early tumor detection in vivo in small animals / Autiero, Maddalena; Cozzolino, R.; Laccetti, Paolo; Marotta, Marcello; Quarto, Maria; Riccio, Patrizia; Roberti, Giuseppe. - In: LASERS IN MEDICAL SCIENCE. - ISSN 0268-8921. - STAMPA. - 24:2(2009), pp. 284-289. [10.1007/s10103-007-0523-1]

Hematoporphyrin-mediated fluorescence reflectance imaging: application to early tumor detection in vivo in small animals.

AUTIERO, MADDALENA;LACCETTI, PAOLO;MAROTTA, MARCELLO;QUARTO, MARIA;RICCIO, PATRIZIA;ROBERTI, GIUSEPPE
2009

Abstract

The in vivo early detection of subcutaneous human tumors implanted in small animals was studied by laser-induced fluorescence reflectance imaging (FRI), with a hematoporphyrin (HP) compound as an exogenous optical contrast agent. Tumor detection was shown to be possible just 3 days after the inoculation of tumor cells, when tumors were neither visible nor palpable. However, this detection capability is limited to a temporal window of approximately 100 h from HP administration and to a low optical contrast of the tumor (<2).
2009
Hematoporphyrin-mediated fluorescence reflectance imaging: application to early tumor detection in vivo in small animals / Autiero, Maddalena; Cozzolino, R.; Laccetti, Paolo; Marotta, Marcello; Quarto, Maria; Riccio, Patrizia; Roberti, Giuseppe. - In: LASERS IN MEDICAL SCIENCE. - ISSN 0268-8921. - STAMPA. - 24:2(2009), pp. 284-289. [10.1007/s10103-007-0523-1]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/351256
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