Continued investigation of cytotoxic exts. of the marine sponge Crella sp. has resulted in the discovery of crellastatins I-M (e.g. I, crellastatin I). Their structures were detd. by interpretation of their NMR spectroscopic and FABMS data. These new bis-steroid derivs. exhibited cytotoxic activity against NSCLC cell lines with IC50 values in the range of 1-8 .mu.g/mL
Isolation and structural elucidation of the crellastatins I-M: cytotoxic bissteroid derivatives from the vanuatu marine sponge Crella sp / Giannini, C.; Zampella, Angela; Debitus, C.; Menou Jean, Louis; Roussakis, C.; D'Auria, MARIA VALERIA. - In: TETRAHEDRON. - ISSN 0040-4020. - STAMPA. - 55:48(1999), pp. 13749-13756. [10.116/S0040-4020(99)00858-3]
Isolation and structural elucidation of the crellastatins I-M: cytotoxic bissteroid derivatives from the vanuatu marine sponge Crella sp
ZAMPELLA, ANGELA;D'AURIA, MARIA VALERIA
1999
Abstract
Continued investigation of cytotoxic exts. of the marine sponge Crella sp. has resulted in the discovery of crellastatins I-M (e.g. I, crellastatin I). Their structures were detd. by interpretation of their NMR spectroscopic and FABMS data. These new bis-steroid derivs. exhibited cytotoxic activity against NSCLC cell lines with IC50 values in the range of 1-8 .mu.g/mLI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
