Heparin-binding hemagglutinin (HBHA) is a virulence factor of tuberculosis which is responsible for extrapulmonary dissemination of this disease. A thorough biochemical characterization of HBHA has provided experimental evidence of a coiled-coil nature of HBHA. These data, together with the low-resolution structures of a full-length form and a truncated form of HBHA obtained by small-angle X-ray scattering, have unambiguously indicated that HBHA has a dimeric structure with an elongated shape.
Evidence for an elongated dimeric structure of heparin-binding hemagglutinin from Mycobacterium tuberculosis / Esposito, C; Pethoukov, Mv; Svergun, Di; Ruggiero, A; Pedone, Carlo; Pedone, E; Berisio, R.. - In: JOURNAL OF BACTERIOLOGY. - ISSN 0021-9193. - STAMPA. - 190:13(2008), pp. 4749-4753.
Evidence for an elongated dimeric structure of heparin-binding hemagglutinin from Mycobacterium tuberculosis.
PEDONE, CARLO;
2008
Abstract
Heparin-binding hemagglutinin (HBHA) is a virulence factor of tuberculosis which is responsible for extrapulmonary dissemination of this disease. A thorough biochemical characterization of HBHA has provided experimental evidence of a coiled-coil nature of HBHA. These data, together with the low-resolution structures of a full-length form and a truncated form of HBHA obtained by small-angle X-ray scattering, have unambiguously indicated that HBHA has a dimeric structure with an elongated shape.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
