A versatile approach to develop libraries of diverse 5’,3’-bis-conjugated oligonucleotides (ODNs) is here described. The usage of ad hoc derivatized solid supports, to which the first nucleoside unit is attached through a phosphate linkage, opens easy synthetic access to a large variety of hybrid bis-conjugated oligomers. The G-quadruplex forming (5’TGGGAG3’) sequence, as a potential anti-HIV agent, has been here used as a model system.
A versatile synthetic approach for the development of libraries of 5’,3’-bis-conjugated oligonucleotides / DI FABIO, Giovanni; C., Coppola; J., D’Onofrio; DE NAPOLI, Lorenzo; Montesarchio, Daniela. - In: NUCLEIC ACIDS SYMPOSIUM SERIES. - ISSN 1746-8272. - STAMPA. - 52:(2008), pp. 299-300. (Intervento presentato al convegno 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids tenutosi a Kyoto (Giappone) nel 8-12 settembre 2008) [10.1093/nass/nrn151].
A versatile synthetic approach for the development of libraries of 5’,3’-bis-conjugated oligonucleotides
DI FABIO, GIOVANNI;DE NAPOLI, LORENZO;MONTESARCHIO, DANIELA
2008
Abstract
A versatile approach to develop libraries of diverse 5’,3’-bis-conjugated oligonucleotides (ODNs) is here described. The usage of ad hoc derivatized solid supports, to which the first nucleoside unit is attached through a phosphate linkage, opens easy synthetic access to a large variety of hybrid bis-conjugated oligomers. The G-quadruplex forming (5’TGGGAG3’) sequence, as a potential anti-HIV agent, has been here used as a model system.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
