The effect of the diisobutyric ester of N-methyldopamine (Ibopamine) on plasma prolactin levels was investigated in normoprolactinaemic subjects and in hyperprolactinaemic patients with prolactin-secreting tumours or idiopathic hyperprolactinaemia. In hyperprolactinaemic states oral Ibopamine 50 mg induced a significant decrease in elevated plasma prolactin (PRL) levels, 30, 60 and 90 min after administration. The peak effect occurred at 90 min when the mean PRL level was 61% of its basal values
Effect of the orally absorbed dopamine analogue N-methyldopamine diisobutyric ester on plasma prolactin levels / Lombardi, Gaetano; Tommaselli, A.; Fariello, C.; Quattrone, A.; Annunziato, Lucio. - In: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. - ISSN 0031-6970. - ELETTRONICO. - 25:1(1983), pp. 131-133.
Effect of the orally absorbed dopamine analogue N-methyldopamine diisobutyric ester on plasma prolactin levels
LOMBARDI, GAETANO;ANNUNZIATO, LUCIO
1983
Abstract
The effect of the diisobutyric ester of N-methyldopamine (Ibopamine) on plasma prolactin levels was investigated in normoprolactinaemic subjects and in hyperprolactinaemic patients with prolactin-secreting tumours or idiopathic hyperprolactinaemia. In hyperprolactinaemic states oral Ibopamine 50 mg induced a significant decrease in elevated plasma prolactin (PRL) levels, 30, 60 and 90 min after administration. The peak effect occurred at 90 min when the mean PRL level was 61% of its basal valuesI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
