250 mg/kg i.p. of the methyl ester of alpha-methyl-p-tyrosine (alpha-MpT) produced a rapid increase (by 1 h) in immunoreactive plasma ACTH, whereas the hypothalamic norepinephrine (NE) concentration and plasma corticosterone (B) changed significantly only 6 h after the administration of the inhibitor. These data suggest that the norepinephrinergic inhibitory tonus of CRF-ACTH secretion depends on the availability of a rapidly utilized pool of transmitter, affected in a very short time by alpha-MpT.
Time-course of the effect of alpha-methyl-p-tyrosine on ACTH secretion / Scapagnini, U.; Annunziato, Lucio; Lombardi, Gaetano; Oliver, G.; Preziosi, P.. - In: NEUROENDOCRINOLOGY. - ISSN 0028-3835. - ELETTRONICO. - 18:(1975), pp. 272-276.
Time-course of the effect of alpha-methyl-p-tyrosine on ACTH secretion.
ANNUNZIATO, LUCIO;LOMBARDI, GAETANO;
1975
Abstract
250 mg/kg i.p. of the methyl ester of alpha-methyl-p-tyrosine (alpha-MpT) produced a rapid increase (by 1 h) in immunoreactive plasma ACTH, whereas the hypothalamic norepinephrine (NE) concentration and plasma corticosterone (B) changed significantly only 6 h after the administration of the inhibitor. These data suggest that the norepinephrinergic inhibitory tonus of CRF-ACTH secretion depends on the availability of a rapidly utilized pool of transmitter, affected in a very short time by alpha-MpT.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
