Galectin-1 and galectin-3 are galactoside-binding proteins involved in different steps of tumor progression and potential targets for therapy. We have investigated the expression of these galectins in 38 human bladder transitional-cell carcinomas of different histological grade and clinical stage and in 5 normal urothelium samples. Galectin-1 mRNA levels were highly increased in most high-grade tumors compared with normal bladder or low-grade tumors. Western blot and immuno-histochemical analysis of normal and neoplastic tissues revealed a higher content of galectin-1 in tumors. Galectin-3 mRNA levels were also increased in most tumors compared with normal urothelium, but levels were comparable among tumors of different histological grade.
galectin-1 and galectin-3 expression in human bladder transitional-cell carcinomas / Cindolo, L., Benvenuto, G., Salvatore, P., Pero, R., Salvatore, G., Mirone, V., Prezioso, D., Altieri, V., Bruni, C.B., Chiariotti, L.. - In: INTERNATIONAL JOURNAL OF CANCER. - ISSN 0020-7136. - 84:1(1999), pp. 39-43. [10.1002/(SICI)1097-0215(19990219)84:1<39::AID-IJC8>3.0.CO;2-E]
galectin-1 and galectin-3 expression in human bladder transitional-cell carcinomas
CINDOLO, LUCA;SALVATORE, PAOLA;PERO, RAFFAELA;BRUNI, CARMELO BRUNO;CHIARIOTTI, LORENZO
1999
Abstract
Galectin-1 and galectin-3 are galactoside-binding proteins involved in different steps of tumor progression and potential targets for therapy. We have investigated the expression of these galectins in 38 human bladder transitional-cell carcinomas of different histological grade and clinical stage and in 5 normal urothelium samples. Galectin-1 mRNA levels were highly increased in most high-grade tumors compared with normal bladder or low-grade tumors. Western blot and immuno-histochemical analysis of normal and neoplastic tissues revealed a higher content of galectin-1 in tumors. Galectin-3 mRNA levels were also increased in most tumors compared with normal urothelium, but levels were comparable among tumors of different histological grade.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
