Gardner's syndrome (GS) is a hereditary disorder inherited as autosomal dominant with complete penetrance and variable expression. GS is a variant of familial adenomatous polyposis characterized by extracolonic manifestations including osteomas, dental anomalies, and epidermoid cysts. The association between GS and endocrine abnormalities has been well documented but a direct pituitary involvement has never been reported. We present a case of oral and maxillofacial manifestations in an adult patient affected by GS associated with growth hormone deficiency, a hitherto unreported association. The possible pathogenic mechanisms are discussed.
Oral and maxillofacial manifestations of Gardner's syndrome associated with growth hormone deficiency: case report and literature review / Ramaglia, Luca; F., Morgese; M., Filippella; Colao, Annamaria. - In: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS. - ISSN 1079-2104. - STAMPA. - 103:(2007), pp. 30-34. [10.1016/j.tripleo.2007.01.013]
Oral and maxillofacial manifestations of Gardner's syndrome associated with growth hormone deficiency: case report and literature review
RAMAGLIA, LUCA;COLAO, ANNAMARIA
2007
Abstract
Gardner's syndrome (GS) is a hereditary disorder inherited as autosomal dominant with complete penetrance and variable expression. GS is a variant of familial adenomatous polyposis characterized by extracolonic manifestations including osteomas, dental anomalies, and epidermoid cysts. The association between GS and endocrine abnormalities has been well documented but a direct pituitary involvement has never been reported. We present a case of oral and maxillofacial manifestations in an adult patient affected by GS associated with growth hormone deficiency, a hitherto unreported association. The possible pathogenic mechanisms are discussed.File | Dimensione | Formato | |
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