A phytochemical study has been carried out on the surface exudate of Salvia x jamensis, which showed a significant platelet antiaggregating activity. The known compounds isopimaric acid (2), 14-α-hydroxy-isopimaric acid (3), 3β-hydroxy-isopimaric acid (4), 7,8β-dihydrosalviacoccin (5), betulinic acid (6), and ursolic acid (7) were isolated together with the new diterpene 1. The structure of 1 was determined as 15,16-epoxy-cleroda-3-en-7α,10β-dihydroxy-12,17;19,18-diolide on the basis of spectroscopic data analysis. Among all tested compounds, 2 showed a significant concentration-dependent antiaggregating activity when ADP (3 μM) was used as agonist on rat platelets. Conversely, 1 increased ADP–induced platelet aggregation.
Platelet antiaggregating activity and chemical constituents of Salvia x jamensis J.Compton / Bisio, A.; Romussi, G.; Russo, E.; DE TOMMASI, N.; Mascolo, NICOLA DOMENICO C. FERDINANDO; Alfieri, Alessio; Bonito, M. C.; Cicala, Carla. - In: NATURAL PRODUCT COMMUNICATIONS. - ISSN 1934-578X. - STAMPA. - 3:6(2008), pp. 881-884.
Platelet antiaggregating activity and chemical constituents of Salvia x jamensis J.Compton
MASCOLO, NICOLA DOMENICO C. FERDINANDO;ALFIERI, ALESSIO;CICALA, CARLA
2008
Abstract
A phytochemical study has been carried out on the surface exudate of Salvia x jamensis, which showed a significant platelet antiaggregating activity. The known compounds isopimaric acid (2), 14-α-hydroxy-isopimaric acid (3), 3β-hydroxy-isopimaric acid (4), 7,8β-dihydrosalviacoccin (5), betulinic acid (6), and ursolic acid (7) were isolated together with the new diterpene 1. The structure of 1 was determined as 15,16-epoxy-cleroda-3-en-7α,10β-dihydroxy-12,17;19,18-diolide on the basis of spectroscopic data analysis. Among all tested compounds, 2 showed a significant concentration-dependent antiaggregating activity when ADP (3 μM) was used as agonist on rat platelets. Conversely, 1 increased ADP–induced platelet aggregation.| File | Dimensione | Formato | |
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Descrizione: Platelet Antiaggregating Activity and Chemical Constituents of Salvia x jamensis J. Compton
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