Eleven quinolone antibacterials have been analyzed by HPLC. The effects of different pH values and organic modifiers on chromatographic behaviour are discussed. Moreover the influence on separation mechanism of different counter-ions at various concentrations in the eluent has been investigated. Two different chromatographic methods have been selected, that allow the simultaneous analysis of quinolones containing or not a piperazinyl moiety, respectively.
High performance liquid chromatographic analysis of quinolone antibacterial agents / Barbato, Francesco; Morrica, Patrizia; Seccia, Serenella; Ventriglia, Mariacarla. - In: IL FARMACO. - ISSN 0014-827X. - STAMPA. - 49:(1994), pp. 407-410.
High performance liquid chromatographic analysis of quinolone antibacterial agents.
BARBATO, FRANCESCO;MORRICA, PATRIZIA;SECCIA, SERENELLA;VENTRIGLIA, MARIACARLA
1994
Abstract
Eleven quinolone antibacterials have been analyzed by HPLC. The effects of different pH values and organic modifiers on chromatographic behaviour are discussed. Moreover the influence on separation mechanism of different counter-ions at various concentrations in the eluent has been investigated. Two different chromatographic methods have been selected, that allow the simultaneous analysis of quinolones containing or not a piperazinyl moiety, respectively.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
