The influence of hyaluronic acid (HA) on the self assembling properties of pluronic (PEO-PPO-PEO block copolymers) blends has been studied with the aim of engineering thermosensitive and mucoadhesive polymeric platforms for drug delivery. The gelation temperature (Tgel), viscoelastic properties and mucoadhesive force of the systems were investigated and optimised by means of rheological analyses. Pluronic micellar radius was evaluated by Photon Correlation Spectroscopy (PCS). The addition of Low Molecular Weight HA did not hamper the self assembling process of pluronics just delaying the gelation temperature of few Celsius degrees. Furthermore, HA presence led to a strong increase of the pluronics gel rheological properties. PCS results show, in formulations containing HA, aggregates with hydrodynamic diameters values much higher than those of pluronic micelles. Mucoadhesive experiments indicate the possibility of interactions between the pluronic/HA gel and mucus glycoproteins.

Effect of Hyaluronic Acid on the Self Assembling Behaviour of PEO-PPO Copolymers in Aqueous Solution / Mayol, Laura; Borzacchiello, A.; Quaglia, Fabiana; LA ROTONDA, MARIA IMMACOLATA; Ambrosio, L.. - STAMPA. - 1027:(2008), pp. 570-572. [10.1063/1.2964768]

Effect of Hyaluronic Acid on the Self Assembling Behaviour of PEO-PPO Copolymers in Aqueous Solution

MAYOL, LAURA;QUAGLIA, FABIANA;LA ROTONDA, MARIA IMMACOLATA;
2008

Abstract

The influence of hyaluronic acid (HA) on the self assembling properties of pluronic (PEO-PPO-PEO block copolymers) blends has been studied with the aim of engineering thermosensitive and mucoadhesive polymeric platforms for drug delivery. The gelation temperature (Tgel), viscoelastic properties and mucoadhesive force of the systems were investigated and optimised by means of rheological analyses. Pluronic micellar radius was evaluated by Photon Correlation Spectroscopy (PCS). The addition of Low Molecular Weight HA did not hamper the self assembling process of pluronics just delaying the gelation temperature of few Celsius degrees. Furthermore, HA presence led to a strong increase of the pluronics gel rheological properties. PCS results show, in formulations containing HA, aggregates with hydrodynamic diameters values much higher than those of pluronic micelles. Mucoadhesive experiments indicate the possibility of interactions between the pluronic/HA gel and mucus glycoproteins.
2008
Effect of Hyaluronic Acid on the Self Assembling Behaviour of PEO-PPO Copolymers in Aqueous Solution / Mayol, Laura; Borzacchiello, A.; Quaglia, Fabiana; LA ROTONDA, MARIA IMMACOLATA; Ambrosio, L.. - STAMPA. - 1027:(2008), pp. 570-572. [10.1063/1.2964768]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/336989
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