Mitochondria are highly specialized organelles and major players in fundamental aspects of cell physiology. In yeast, energy metabolism and coupling of mitochondrial activity to growth and survival is controlled by the protein kinase A pathway. In higher eukaryotes, modulation of the so-called A-kinase anchor protein (AKAP) complex regulates mitochondrial dynamics and activity, adapting the oxidative machinery and the metabolic pathway to changes in physiological demand. Protein kinases and phosphatases are assembled by AKAPs within transduction units, providing a mechanism to control signaling events at mitochondria and other target organelles. Ubiquitin-mediated proteolysis of signal transducers and effectors provides an additional layer of complexity in the regulation of mitochondria homeostasis. Genetic evidence indicates that alteration of one or more components of these biochemical pathways leads to mitochondrial dysfunction and human diseases. In this review, we focus on the emerging role of AKAP scaffolds and the proteasome pathway in the control of oxidative metabolism, organelle dynamics and the mitochondrial signaling network. These aspects are crucial elements for maintaining a proper energy balance and cellular lifespan.

Control of mitochondria dynamics and oxidative metabolism by cAMP, AKAPs and the proteasome / Carlucci, Annalisa; Lignitto, L; Feliciello, Antonio. - In: TRENDS IN CELL BIOLOGY. - ISSN 0962-8924. - STAMPA. - 18:(2008), pp. 604-613. [10.1016/j.tcb.2008.09.006]

Control of mitochondria dynamics and oxidative metabolism by cAMP, AKAPs and the proteasome.

CARLUCCI, ANNALISA;FELICIELLO, ANTONIO
2008

Abstract

Mitochondria are highly specialized organelles and major players in fundamental aspects of cell physiology. In yeast, energy metabolism and coupling of mitochondrial activity to growth and survival is controlled by the protein kinase A pathway. In higher eukaryotes, modulation of the so-called A-kinase anchor protein (AKAP) complex regulates mitochondrial dynamics and activity, adapting the oxidative machinery and the metabolic pathway to changes in physiological demand. Protein kinases and phosphatases are assembled by AKAPs within transduction units, providing a mechanism to control signaling events at mitochondria and other target organelles. Ubiquitin-mediated proteolysis of signal transducers and effectors provides an additional layer of complexity in the regulation of mitochondria homeostasis. Genetic evidence indicates that alteration of one or more components of these biochemical pathways leads to mitochondrial dysfunction and human diseases. In this review, we focus on the emerging role of AKAP scaffolds and the proteasome pathway in the control of oxidative metabolism, organelle dynamics and the mitochondrial signaling network. These aspects are crucial elements for maintaining a proper energy balance and cellular lifespan.
2008
Control of mitochondria dynamics and oxidative metabolism by cAMP, AKAPs and the proteasome / Carlucci, Annalisa; Lignitto, L; Feliciello, Antonio. - In: TRENDS IN CELL BIOLOGY. - ISSN 0962-8924. - STAMPA. - 18:(2008), pp. 604-613. [10.1016/j.tcb.2008.09.006]
File in questo prodotto:
File Dimensione Formato  
TiCB 2008.pdf

non disponibili

Tipologia: Abstract
Licenza: Accesso privato/ristretto
Dimensione 1.02 MB
Formato Adobe PDF
1.02 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/336913
Citazioni
  • ???jsp.display-item.citation.pmc??? 66
  • Scopus 113
  • ???jsp.display-item.citation.isi??? 112
social impact