{Background: The aim of this study is to evaluate the rate of infectious complications post endoscopic transspheinodal neurosurgery in patients receiving a new antibiotic chemoprophylaxis regimen. Methods: Clinical records of 170 patients who received prophylaxis with a third-generation cephalosporin plus aminoglycoside (160 cases) or alone (10 cases) were retrospectively analyzed. Twenty-eight patients (16.4\%) had CSF leakage. The postsurgical follow-up ranged from 3 months to 4 years. Results: Of 170 patients, 2 (1.17\%) developed infectious complications: 1 case of meningitis by Staphylococcus epidermidis and 1 case of sphenoid sinusitis (without microbiological diagnosis). In addition, asymptomatic sphenoid sinusitis was diagnosed in 2 other patients. The cost ranged from 22.50 to 33.34 euros/d. Conclusions: The rate of infectious complications was very low in patients receiving prophylaxis with a third-generation cephalosporin plus aminoglycoside or alone; because of the broad-spectrum of antibiotics and their high cost, this regimen could be used in at-risk patients (eg, smokers, patients with cerebrospinal leak, or patients with Cushing diseases). (c) 2007 Elsevier Inc. All rights reserved.}
Retrospective analysis of a new antibiotic chemoprophylaxis regimen in 170 patients undergoing endoscopic endonasal transsphenoidal surgery / Orlando, Raffaele; Cappabianca, Paolo; Tosone, Grazia; Esposito, F.; Piazza, Marcello; DE DIVITIIS, Enrico. - In: SURGICAL NEUROLOGY. - ISSN 0090-3019. - STAMPA. - 68:(2007), pp. 145-148.
Retrospective analysis of a new antibiotic chemoprophylaxis regimen in 170 patients undergoing endoscopic endonasal transsphenoidal surgery
ORLANDO, RAFFAELE;CAPPABIANCA, PAOLO;TOSONE, GRAZIA;F. ESPOSITO;PIAZZA, MARCELLO;DE DIVITIIS, ENRICO
2007
Abstract
{Background: The aim of this study is to evaluate the rate of infectious complications post endoscopic transspheinodal neurosurgery in patients receiving a new antibiotic chemoprophylaxis regimen. Methods: Clinical records of 170 patients who received prophylaxis with a third-generation cephalosporin plus aminoglycoside (160 cases) or alone (10 cases) were retrospectively analyzed. Twenty-eight patients (16.4\%) had CSF leakage. The postsurgical follow-up ranged from 3 months to 4 years. Results: Of 170 patients, 2 (1.17\%) developed infectious complications: 1 case of meningitis by Staphylococcus epidermidis and 1 case of sphenoid sinusitis (without microbiological diagnosis). In addition, asymptomatic sphenoid sinusitis was diagnosed in 2 other patients. The cost ranged from 22.50 to 33.34 euros/d. Conclusions: The rate of infectious complications was very low in patients receiving prophylaxis with a third-generation cephalosporin plus aminoglycoside or alone; because of the broad-spectrum of antibiotics and their high cost, this regimen could be used in at-risk patients (eg, smokers, patients with cerebrospinal leak, or patients with Cushing diseases). (c) 2007 Elsevier Inc. All rights reserved.}File | Dimensione | Formato | |
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