Seven angiotensin-converting-enzyme (ACE) inhibitors have been analyzed by HPLC. The influence of different organic modifiers and counter-ions in the eluent at different pH values have been investigated allowing the identification of the best experimental conditions for the analysis of these compounds. The sinergic effect of TEA and propanol in the eluents resulted as a critical factor to obtain satisfactory peak shapes and resolution.

Analysis of ACE inhibitor drugs by high performance liquid chromatography.

BARBATO, FRANCESCO;MORRICA, PATRIZIA;QUAGLIA, FABIANA
1994

Abstract

Seven angiotensin-converting-enzyme (ACE) inhibitors have been analyzed by HPLC. The influence of different organic modifiers and counter-ions in the eluent at different pH values have been investigated allowing the identification of the best experimental conditions for the analysis of these compounds. The sinergic effect of TEA and propanol in the eluents resulted as a critical factor to obtain satisfactory peak shapes and resolution.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/336319
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