The aim of the present work was to develop a family of novel materials based on a combination of sodium alginate and acrylic polymers and to evaluate their potential in drug delivery applications. In the presence of sodium alginate, acrylic chains with acidic as well as basic moieties were polymerized to create an interpolymer complex based on electrostatic interactions that are able to modulate the release rate of low molecular weight drugs. The synthesized materials were used to prepare hydrophilic matrices for drug delivery and tested for their adhesion properties to glass, used as a model substrate for mucoadhesion.
Novel alginate-acrylic polymers as a platform for drug delivery / P., Laurienzo; M., Malinconico; G., Mattia; R., Russo; LA ROTONDA, MARIA IMMACOLATA; Quaglia, Fabiana; D., Capitani; L., Mannina. - In: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART A. - ISSN 1549-3296. - STAMPA. - 78:(2006), pp. 523-531.
Novel alginate-acrylic polymers as a platform for drug delivery.
LA ROTONDA, MARIA IMMACOLATA;QUAGLIA, FABIANA;
2006
Abstract
The aim of the present work was to develop a family of novel materials based on a combination of sodium alginate and acrylic polymers and to evaluate their potential in drug delivery applications. In the presence of sodium alginate, acrylic chains with acidic as well as basic moieties were polymerized to create an interpolymer complex based on electrostatic interactions that are able to modulate the release rate of low molecular weight drugs. The synthesized materials were used to prepare hydrophilic matrices for drug delivery and tested for their adhesion properties to glass, used as a model substrate for mucoadhesion.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
