BACKGROUND: Fatigue is a major problem in multiple sclerosis (MS), and its association with MRI features is debated. OBJECTIVE: To study the correlation between fatigue and lesion load, white matter (WM), and grey matter (GM), in MS patients independent of disability. METHODS: We studied 222 relapsing remitting MS patients with low disability (scores <or=2 at the Kurtzke Expanded Disability Status Scale). Lesion load, WM and GM were measured by fully automated, operator-independent, multi-parametric segmentation method. T1 and T2 lesion volume were also measured by a semi-automated method. Fatigue was assessed by the Fatigue Severity Scale (FSS), and patients divided in high-fatigue (FSS>or=5; n=197) and low-fatigue groups (FSS<or=4; n=25). RESULTS: High-fatigue patients showed significantly higher abnormal white matter fraction (AWM-f), T1 and T2 lesion loads, and significant lower WM-f, and GM-f. Multivariate analysis showed that high FSS was significantly associated with lower WM-f, and GM-f. Females and highly educated patients were significantly less fatigued. CONCLUSION: These results suggest that among MS patients with low disability those with high-fatigue show higher WM and GM atrophy and higher lesion load, and that female sex and higher levels of education may play a protective role towards fatigue. Furthermore, they suggest that in MS, independent of disability, WM and GM atrophy is a risk factor to have fatigue.

Correlation between fatigue and brain atrophy and lesion load in multiple sclerosis patients independent of disability / Tedeschi, G; Dinacci, D; Lavorgna, L; Prinster, A; Savettieri, G; Quattrone, A; Livrea, P; Messina, C; Reggio, A; Servillo, Giuseppe; BRESCIA MORRA, Vincenzo; Orefice, Giuseppe; Paciello, M; Brunetti, Arturo; Paolillo, A; Coniglio, G; Bonavita, S; Di Costanzo, A; Bellacosa, A; Valentino, P; Quarantelli, M; Patti, F; Salemi, G; Cammarata, E; Simone, I; Salvatore, Marco; Bonavita, Vincenzo; Alfano, B.. - In: JOURNAL OF THE NEUROLOGICAL SCIENCES. - ISSN 0022-510X. - STAMPA. - 263:1-2(2007), pp. 15-19.

Correlation between fatigue and brain atrophy and lesion load in multiple sclerosis patients independent of disability.

SERVILLO, GIUSEPPE;BRESCIA MORRA, VINCENZO;OREFICE, GIUSEPPE;BRUNETTI, ARTURO;SALVATORE, MARCO;BONAVITA, VINCENZO;
2007

Abstract

BACKGROUND: Fatigue is a major problem in multiple sclerosis (MS), and its association with MRI features is debated. OBJECTIVE: To study the correlation between fatigue and lesion load, white matter (WM), and grey matter (GM), in MS patients independent of disability. METHODS: We studied 222 relapsing remitting MS patients with low disability (scores or=5; n=197) and low-fatigue groups (FSS
2007
Correlation between fatigue and brain atrophy and lesion load in multiple sclerosis patients independent of disability / Tedeschi, G; Dinacci, D; Lavorgna, L; Prinster, A; Savettieri, G; Quattrone, A; Livrea, P; Messina, C; Reggio, A; Servillo, Giuseppe; BRESCIA MORRA, Vincenzo; Orefice, Giuseppe; Paciello, M; Brunetti, Arturo; Paolillo, A; Coniglio, G; Bonavita, S; Di Costanzo, A; Bellacosa, A; Valentino, P; Quarantelli, M; Patti, F; Salemi, G; Cammarata, E; Simone, I; Salvatore, Marco; Bonavita, Vincenzo; Alfano, B.. - In: JOURNAL OF THE NEUROLOGICAL SCIENCES. - ISSN 0022-510X. - STAMPA. - 263:1-2(2007), pp. 15-19.
File in questo prodotto:
File Dimensione Formato  
Tedeschi_JNS_2007.pdf

non disponibili

Tipologia: Documento in Post-print
Licenza: Accesso privato/ristretto
Dimensione 124.69 kB
Formato Adobe PDF
124.69 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/335771
Citazioni
  • ???jsp.display-item.citation.pmc??? 26
  • Scopus 117
  • ???jsp.display-item.citation.isi??? 100
social impact