Several markers of systemic inflammation appear to be active effectors in the pathophysiology of acute coronary syndrome and its evolution. High mobility group box-1 (HMGB-1), a ubiquitous nuclear protein constitutively expressed in quiescent cells, was recently recognized as a newer critical mediator of inflammatory diseases. The present study demonstrated that in postinfarction patient, HMGB-1 levels were significantly higher compared to healthy controls, and significantly correlated with cardiopulmonary and Doppler-echocardiography parameters.
Increased High Mobility Group Box-1 protein levels are associated with impaired cardiopulmonary and echocardiographic findings after acute myocardial infarction / Cirillo, Plinio; Giallauria, Francesco; Pacileo, M; Petrillo, G; D’ Agostino, M; Vigorito, C; Chiariello, M.. - In: JOURNAL OF CARDIAC FAILURE. - ISSN 1071-9164. - STAMPA. - 15:(2009), pp. 362-367. [10.1016/j.cardfail.2008.11.010]
Increased High Mobility Group Box-1 protein levels are associated with impaired cardiopulmonary and echocardiographic findings after acute myocardial infarction.
CIRILLO, PLINIO;GIALLAURIA, FRANCESCO;
2009
Abstract
Several markers of systemic inflammation appear to be active effectors in the pathophysiology of acute coronary syndrome and its evolution. High mobility group box-1 (HMGB-1), a ubiquitous nuclear protein constitutively expressed in quiescent cells, was recently recognized as a newer critical mediator of inflammatory diseases. The present study demonstrated that in postinfarction patient, HMGB-1 levels were significantly higher compared to healthy controls, and significantly correlated with cardiopulmonary and Doppler-echocardiography parameters.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
