t is widely accepted that a critical factor in determining neuronal death during cerebral ischemia is the progressive accumulation of intracellular Na+ ([Na+]i) and Ca2+ ([Ca2+]i) ions, which can precipitate necrosis and apoptosis of vulnerable neurons. Whereas the detrimental action of [Na+]i increase is attributable to both cell swelling and microtubular disorganization—2 phenomena that lead to cell necrosis1—a change in [Ca2+]i has been shown to be a key factor in ischemic brain damage, for it modulates several death pathways, including oxidative and nitrosative stress, mitochondrial dysfunction, and protease activation.

Glutamate-independent calcium toxicity: introduction / Annunziato, Lucio; Cataldi, Mauro; Pignataro, Giuseppe; Secondo, Agnese; Molinaro, Pasquale. - In: STROKE. - ISSN 0039-2499. - STAMPA. - 38:2 Suppl(2007), pp. 661-664. [10.1161/01.STR.0000247942.42349.37]

Glutamate-independent calcium toxicity: introduction

ANNUNZIATO, LUCIO;CATALDI, MAURO;PIGNATARO, GIUSEPPE;SECONDO, AGNESE;MOLINARO, PASQUALE
2007

Abstract

t is widely accepted that a critical factor in determining neuronal death during cerebral ischemia is the progressive accumulation of intracellular Na+ ([Na+]i) and Ca2+ ([Ca2+]i) ions, which can precipitate necrosis and apoptosis of vulnerable neurons. Whereas the detrimental action of [Na+]i increase is attributable to both cell swelling and microtubular disorganization—2 phenomena that lead to cell necrosis1—a change in [Ca2+]i has been shown to be a key factor in ischemic brain damage, for it modulates several death pathways, including oxidative and nitrosative stress, mitochondrial dysfunction, and protease activation.
2007
Glutamate-independent calcium toxicity: introduction / Annunziato, Lucio; Cataldi, Mauro; Pignataro, Giuseppe; Secondo, Agnese; Molinaro, Pasquale. - In: STROKE. - ISSN 0039-2499. - STAMPA. - 38:2 Suppl(2007), pp. 661-664. [10.1161/01.STR.0000247942.42349.37]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/335482
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