Seven years after a surgically resected thymoma, a female patient affected by myasthenia gravis and Good's syndrome presented with paroxysmal nocturnal hemoglobinuria (PNH). Co-culture experiments and spectratyping analyses indicated that CD8+ lymphocytes were involved in damaging hematopoietic precursors. While PNH clones have been identified in various hematological disorders, the sequential association of thymoma and PNH has been unreported so far.
Thymoma followed by paroxysmal nocturnal hemoglobinuria: a unique clinique association in the context of multiorgan autoimmunity with a potential role for CD8+ T lymphocytes / Palmieri, Giovannella; Selleri, Carmine; L., Montella; G., Bulgarelli; L., Vitello; G., Merkabaou; P., Ricci; DEL VECCHIO, Luigi; A., Masci; Racioppi, Luigi; Rotoli, Bruno. - In: AMERICAN JOURNAL OF HEMATOLOGY. - ISSN 0361-8609. - STAMPA. - 81:(2006), pp. 774-778. [10.1002/ajh.20699]
Thymoma followed by paroxysmal nocturnal hemoglobinuria: a unique clinique association in the context of multiorgan autoimmunity with a potential role for CD8+ T lymphocytes.
PALMIERI, GIOVANNELLA;SELLERI, CARMINE;DEL VECCHIO, LUIGI;RACIOPPI, LUIGI;ROTOLI, BRUNO
2006
Abstract
Seven years after a surgically resected thymoma, a female patient affected by myasthenia gravis and Good's syndrome presented with paroxysmal nocturnal hemoglobinuria (PNH). Co-culture experiments and spectratyping analyses indicated that CD8+ lymphocytes were involved in damaging hematopoietic precursors. While PNH clones have been identified in various hematological disorders, the sequential association of thymoma and PNH has been unreported so far.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
